Joitakin kertoja olen maininnut huonosta uskostani predentinaatio-oppiin (ennaltam??r??mis-), mit? tulee perim??n.
Joka suvussa on hevosvarkaansa.
Geeneille emme voi mit??n. Niiden kanssa pit?? el?? ja tulla toimeen.
Koko aineenvaihdunnan sokeri- ja rasvaosuuteen kertyy nopeasti tietoa.
Voiko T2DM:n ja muut (sv-taudit, lihavuus jne) v?ltt?? huonosta perim?st? huolimatta?
Itse uskon niin. Voi jopa p?rj?t? jo puhjenneiden tautien kanssa sopuisassa rinnakkaiselossa.
Pient? lis?? t?h?n antaan hyv?n julkaisufoorumin tuore tuote:
1: Am J Clin Nutr. 2009 Feb 11. [Epub ahead of print]
TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women.
Cornelis MC, Qi L, Kraft P, Hu FB.
Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, and the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
BACKGROUND: TCF7L2 is the strongest type 2 diabetes (T2D) locus identified to date, and evidence suggests it plays an important role in insulin synthesis, processing, and secretion. Dietary factors that increase the insulin demand might enhance the risk of T2D associated with TCF7L2 variants. OBJECTIVE: The objective was to determine whether the risk of T2D associated with TCF7L2 is modified by the glycemic load (GL), glycemic index (GI), cereal fiber content, and total carbohydrate content of the diet. DESIGN: T2D cases (n = 1140) and controls (n = 1915) from the Nurses' Health Study were genotyped for TCF7L2 (rs12255372). Dietary intake was assessed with a semiquantitative food-frequency questionnaire. RESULTS: Significant differences in odds ratios (ORs) of T2D associated with the TCF7L2 genotype between high and low strata of GL (P = 0.03) and GI (P = 0.05) were suggested. Compared with the GG genotype, multivariate-adjusted ORs (95% CI) of T2D associated with the TT genotype were 2.71 (1.64, 4.46) and 2.69 (1.64, 4.43) among individuals in the highest tertile of GL and GI, respectively. Corresponding ORs (95% CIs) among individuals in the lowest tertiles of GL and GI were 1.66 (0.95, 2.88) and 1.82 (1.11, 3.01). The risk of T2D associated with the TCF7L2 single nucleotide polymorphism did not significantly differ by cereal fiber or carbohydrate intake. Conclusion: Carbohydrate quality and quantity modified risk of T2D associated with TCF7L2, which suggests that changes in risk attributable to the TCF7L2 variant are magnified under conditions of increased insulin demand.
Lihavoinnit T.K., hymi? tuli talon puolesta mit??n tekem?tt
Timo Kuusela, LKT, radiologi, eläk.