Valvoja: Timo Kuusela
Background: Some studies have reported that the increase in VLDL- triacylglycerols concentration after a high fructose diet (HFrD) was more pronounced in men compared with pre-menopausal females
Objective: Since HFrD may increase VLDL-triacylglycerols through stimulation of hepatic de novo lipogenesis (DNL), we hypothesized that fructose-induced stimulation of DNL is blunted in pre-menopausal women.
Design: Nine healthy male and nine healthy female subjects were studied after ingestion of oral loads of fructose enriched with ^13 C_6 fructose. Incorporation of ^13 C into breath CO_2 , plasma glucose, and plasma VLDL-palmitate were monitored to evaluate total fructose oxidation, gluconeogenesis, and hepatic DNL respectively. Substrate oxidation was assessed by indirect calorimetry.
Results: Total fructose oxidation and conversion of fructose to glucose were stimulated to the same extent after fructose ingestion in males and females. However the ^13 C enrichment of VLDL palmitate rose significantly in males, but remained close to zero in females (/P/ < 0.005). Furthermore lipid oxidation was significantly less suppressed in females than in males (/P/ < 0.05).
Conclusions: The results support the hypothesis that females may be protected against fructose induced-hypertriglyceridemia because of a lower stimulation of DNL and a lower suppression of lipid oxidation.
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